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ABSTRACT: The abstract should include: 1) A statement of the research question or objective, including a statement that one objective is to provide regular updates and keep the review live. This version is update XXX of the original article published XXXXXX (give BMJ DOI), and previous updates can be found as data supplements wht link).

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Copies of meaxure related articles you have published (this what does your waistline measure particularly important when details of the study llc novartis pharma are published elsewhere). Copies of any previous reviewers' reports on this article. We appreciate that authors may have tried other journals before sending their work to The BMJ, and find it helpful if you let us know how you have responded to previous reviewers' comments.

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